Symbol
Name
ID

Nkx2-2
NK2 homeobox 2
MGI:97347

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

abnormal pancreatic beta cell differentiation

endocrine/exocrine gland phenotype

abnormal pancreatic islet morphology

decreased PP cell number

decreased pancreatic alpha cell number

increased pancreatic alpha cell number

decreased pancreatic beta cell number

absent pancreatic beta cells

increased pancreatic epsilon cell number

small pancreatic islets

disorganized pancreatic islets

abnormal pancreas morphology

decreased glucagon secretion

decreased insulin secretion

abnormal pancreas physiology

Availability

Mouse Genotype

Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr

Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss

Nkx2-2^tm3Suss/Nkx2-2^tm3Suss

Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss

Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss
Tg(Pdx1-cre)6Tuv/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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